2013 Volume 8 Issue 3
Article Contents

Lou Qinqin, Tian Mi, Qin Zhanfen, Wei Wuji. Research Progress in Non-Monotonic Dose-Response of Endocrine Disruptors[J]. Asian Journal of Ecotoxicology, 2013, 8(3): 295-305. doi: 10.7524/AJE.1673-5897.20081209002
Citation: Lou Qinqin, Tian Mi, Qin Zhanfen, Wei Wuji. Research Progress in Non-Monotonic Dose-Response of Endocrine Disruptors[J]. Asian Journal of Ecotoxicology, 2013, 8(3): 295-305. doi: 10.7524/AJE.1673-5897.20081209002

Research Progress in Non-Monotonic Dose-Response of Endocrine Disruptors

  • Received Date: 09/12/2008
    Fund Project:
  • In traditional toxicology theory, the dose-response relationship caused by toxicants is linear and monotonic. Linear dose-response relationship is the theoretical base for calculating the safe dose of chemicals. However, more and more studies have shown that dose-responses of endocrine disruptors are non-linear, i. e. U-shaped, inverted U-shaped or more complicated non-monotonic dose-response curves. We introduced the research progress in non-monotonic doseresponse of hormones and endocrine disruptors by illustrating typical examples and summarized several mechanisms for non-monotonic dose-response. Then, we discussed the challenges that non-monotonic dose-response brings to risk assessment for chemicals in traditional regulatory toxicology.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2526) PDF downloads(42) Cited by(0)

Access History

Research Progress in Non-Monotonic Dose-Response of Endocrine Disruptors

Fund Project:

Abstract: In traditional toxicology theory, the dose-response relationship caused by toxicants is linear and monotonic. Linear dose-response relationship is the theoretical base for calculating the safe dose of chemicals. However, more and more studies have shown that dose-responses of endocrine disruptors are non-linear, i. e. U-shaped, inverted U-shaped or more complicated non-monotonic dose-response curves. We introduced the research progress in non-monotonic doseresponse of hormones and endocrine disruptors by illustrating typical examples and summarized several mechanisms for non-monotonic dose-response. Then, we discussed the challenges that non-monotonic dose-response brings to risk assessment for chemicals in traditional regulatory toxicology.

Reference (0)

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint