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  • 刘瑞霞,李佳熹,刘晓玲.环境介质中手性药物对映体分离分析及环境行为研究进展[J].环境工程学报,2017,11(6):3341-3351.DOI:10.12030/j.cjee.201704158    [点击复制]
  • LIU Ruixia,LI Jiaxi,LIU Xiaoling.Research progress on separation, analysis and environmental behavior of chiral pharmaceutical enantiomers in environmental matrix[J].,2017,11(6):3341-3351.DOI:10.12030/j.cjee.201704158   [点击复制]
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环境介质中手性药物对映体分离分析及环境行为研究进展
刘瑞霞1,2, 李佳熹1,2, 刘晓玲1,2
0
(1. 中国环境科学研究院环境基准与风险评估国家重点实验室, 北京 100012;2. 中国环境科学研究院城市水环境科技创新基地, 北京 100012)
摘要:
综述了国内外环境介质中手性药物的分离分析方法以及环境行为研究进展,对比了几种主要的对映体分离方法,对手性固定相的种类及特性、分离原理、影响因素和发展趋势作了简要介绍,探讨了药物对映体在污水处理工艺和天然水环境中的降解或转化规律等环境行为,介绍了药物对映体特性在污染物源解析中的应用。
关键词:  环境介质  药物对映体  分离检测方法  环境行为
DOI:10.12030/j.cjee.201704158
投稿时间:2016-09-03修订日期:2016-10-14
基金项目:国家自然科学基金资助项目(21277133)
Research progress on separation, analysis and environmental behavior of chiral pharmaceutical enantiomers in environmental matrix
LIU Ruixia1,2, LI Jiaxi1,2, LIU Xiaoling1,2
(1. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China;2. Department of Urban Water Environmental Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China)
Abstract:
This paper reviewed the research progress on separation, analytical methods of chiral pharmaceuticals in the environmental samples and their environmental behaviors in aquatic environment. The main separation methods of enantiomers were compared. The types, characteristics, separation principle and influence factors of chiral stationary phase for the separation of enantiomers was described in detail, accordingly, development trend on enantiomers separation was proposed. Additionally, the degradation and transformation of pharmaceutical enantiomers in sewage treatment processes and natural water, as well as application of enantiomeric selectivity for chiral pharmaceuticals in the pollutant source apportionment were reviewed and discussed.
Key words:  environmental matrix  drug enantiomers  separation and detection method  environmental behavior