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增塑剂DEHP神经毒性作用及机制的研究进展

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王婷, 高星梅, 郭会彩, 刘诣, 王磊. 增塑剂DEHP神经毒性作用及机制的研究进展[J]. 生态毒理学报, 2022, 17(2): 33-42. doi: 10.7524/AJE.1673-5897.20210503001
引用本文: 王婷, 高星梅, 郭会彩, 刘诣, 王磊. 增塑剂DEHP神经毒性作用及机制的研究进展[J]. 生态毒理学报, 2022, 17(2): 33-42. doi: 10.7524/AJE.1673-5897.20210503001
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Wang Ting, Gao Xingmei, Guo Huicai, Liu Yi, Wang Lei. Research Progress on Neurotoxic Effects and Mechanism of Plasticizer DEHP[J]. Asian Journal of Ecotoxicology, 2022, 17(2): 33-42. doi: 10.7524/AJE.1673-5897.20210503001
Citation: Wang Ting, Gao Xingmei, Guo Huicai, Liu Yi, Wang Lei. Research Progress on Neurotoxic Effects and Mechanism of Plasticizer DEHP[J]. Asian Journal of Ecotoxicology, 2022, 17(2): 33-42. doi: 10.7524/AJE.1673-5897.20210503001
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增塑剂DEHP神经毒性作用及机制的研究进展

  • 1. 河北医科大学公共卫生学院，石家庄 050017;

  • 2. 河北省环境与人群健康重点实验室，石家庄 050017;

  • 3. 河北医科大学药学院，石家庄 050017

    • 作者简介: 王婷(1995—)，女，硕士研究生，研究方向为卫生毒理学，E-mail: 1126224353@qq.com
    通讯作者: 刘诣, E-mail: liuyi78@hebmu.edu.cn ;  王磊, E-mail: wanglei_roy@hotmail.com
  • 基金项目:

    河北省自然科学基金资助项目(H2020206584)；河北省教育厅重点项目(ZD20190440)

  • 中图分类号: X171.5

Research Progress on Neurotoxic Effects and Mechanism of Plasticizer DEHP

  • 1. School of Public Health, Hebei Medical University, Shijiazhuang 050017, China;

  • 2. Hebei Key Laboratory of Environment and Human Health, Shijiazhuang 050017, China;

  • 3. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China

    • Corresponding authors: Liu Yi, liuyi78@hebmu.edu.cn ;  Wang Lei, wanglei_roy@hotmail.com
  • Fund Project:

  • 摘要: 近年来，增塑剂邻苯二甲酸二(2-乙基己)酯(di-(2-ethylhexyl) phthalate, DEHP)的神经毒性作用越来越受到人们的关注。DEHP可通过多种途径进入脑组织并作用于中枢神经系统，导致各种损伤。因此，笔者系统阐述DEHP进入脑组织的途径、神经毒性作用表现及其机制，为今后深入研究DEHP的健康效应及分子机制，制定更为合理的、针对不同暴露人群的安全限值和暴露限值提供理论参考。
    Abstract: In recent years, the neurotoxicity of the plasticizer di-(2-ethylhexyl) phthalate (DEHP) has attracted more and more attention. DEHP can enter the brain tissue through a variety of routes and act on the central nervous system, causing various injuries. Therefore, this review systematically elucidates the ways that DEHP enters the brain tissue, its neurotoxic effects and underlying mechanisms so as to provide recommendations for future research on the health effects and molecular mechanisms of DEHP, and also to provide references to develop more reasonable safety and exposure limits for different exposed groups.
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  • 收稿日期:  2021-05-03

增塑剂DEHP神经毒性作用及机制的研究进展

    通讯作者: 刘诣, E-mail: liuyi78@hebmu.edu.cn ;  王磊, E-mail: wanglei_roy@hotmail.com
    作者简介: 王婷(1995—)，女，硕士研究生，研究方向为卫生毒理学，E-mail: 1126224353@qq.com
  • 1. 河北医科大学公共卫生学院，石家庄 050017;
  • 2. 河北省环境与人群健康重点实验室，石家庄 050017;
  • 3. 河北医科大学药学院，石家庄 050017
  • 收稿日期:  2021-05-03
基金项目:

河北省自然科学基金资助项目(H2020206584)；河北省教育厅重点项目(ZD20190440)

摘要: 近年来，增塑剂邻苯二甲酸二(2-乙基己)酯(di-(2-ethylhexyl) phthalate, DEHP)的神经毒性作用越来越受到人们的关注。DEHP可通过多种途径进入脑组织并作用于中枢神经系统，导致各种损伤。因此，笔者系统阐述DEHP进入脑组织的途径、神经毒性作用表现及其机制，为今后深入研究DEHP的健康效应及分子机制，制定更为合理的、针对不同暴露人群的安全限值和暴露限值提供理论参考。

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